Relationship between human parvovirus B19 infection and Kawasaki disease in children

    CAO Yuª²Hong1,ZHANG Guangª²Yun2,ZHANG Guoª²Cheng1,DING Cuiª²Ling1,CAO Yanª²Hua3,YANG Xinª²Wei1,SHEN Qing1

    1Department of Pediatrics,2Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi¬ðan710033,China,3Department of Pediatrics,Jinan General Hospital,Jinan Military Command,Jinan 250031,China

    ¡¾Abstract¡¿ AIM: To study the relationship between human parvovirus B19 infection and Kawasaki disease in children.METHODS: Nested PCR was used to detect serum B19ª²DNA in 46 children with Kawasaki disease and ELISA was used to detect serum B19ª²VP2ª²IgM in 30 patients.Fifty healthy children were used as control.RESULTS: Fourteen(30ª±4%) of the 46 patients in the case group and 2(4ª±0%) of the 50 healthy children in the control group were positive for B19ª²DNA(P<0ª±01).Seven (23ª±3%) of the 30 patients in the case group and none of the children in the control group were positive for B19ª²VP2ª²IgM (P<0ª±01). Of the 30 patients in the case group whose B19ª²DNA and B19ª²VP2ª²IgM were tested,6 were positive for both B19ª²DNA and B19ª²VP2ª²IgM,while another 4 were only positive for B19ª²DNA and 1 for B19ª²VP2ª²IgM ......