抗生素治疗原发性腹膜炎患者对血浆一氧化氮、内毒素及门脉血流动力学的影响
原发性腹膜炎,,原发性腹膜炎；一氧化氮；血流动力学,1对象与方法,2结果,3讨论,【参考文献】
【摘要】 目的 研究抗生素治疗肝硬化原发性腹膜炎病人对血浆一氧化氮、内毒素及门脉血流的影响。方法 用抗生素治疗肝硬化原发性腹膜炎病人47例，检测治疗前、后病人血浆一氧化氮(NO)、内毒素水平(LPS)；用彩色多普勒检测治疗前、后门脉主干内径、门脉主干及门脉左支矢状部血流速度。结果 治疗后血浆NO、内毒素水平明显低于治疗前(P<0.035、0.044)；门脉主干及门脉左支矢状部血流速度较治疗前明显增加(P<0.025、0.05)；但门脉内径无明显变化(P<0.07)。结论 抗生素治疗肝硬化原发性腹膜炎可降低血浆NO、内毒素水平，增加门静脉血流。【关键词】 原发性腹膜炎；一氧化氮；血流动力学
Influence of the spontaneous bacteria peritonitis of cirrhotic patients treated with antibiotics on level of NO,LPS and portal vein flow
XU Guangda,LAI Shaotong,DENG Zhaobin,et al.Department of General Surgery,The Affiliated Xinhua Hospital of Dalian University,Dalian 116021,China
【Abstract】 Objective To investigate influence of cirrhotic patients accompanying by spontaneous bacterial peritonitis treated by antibiotics on levels of LPS,NO in the serum and portal hypertension.Methods 47 cases of cirrhotic patients accompanying by spontaneous bacteria peritonitis(SBP) treated by antibiotics for 10～14 days,the levels of LPS,NO in serum were assayed before and after treatment,the changes of diameter of the common portal vein(DPV),velocity of blood flow(VPV)of the common portal vein and UPV were determined.Results Before treatment the levels of LPS in serum was significantly lower than that of LPS in the serum(P<0.05) velocity of blood flow of common portal vein and UPV before treatment were markedly lower than those after treatment(P<0.05) ......
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