摘要: 补体受体1型(Complement receptor type1，CR1)具有外源性及内源性活性，既可灭活组装于非自身细胞膜上的C3.C5转化酶，也可灭活自身细胞膜上形成的C3.C5转化酶。CR1是唯一既对经典、替代及植物凝集素(MBL)3个补体激活途径的，对C3.C5转化酶拥有衰变加速活性，又有辅助1因子裂解C3b和C4b作用的补体调节蛋白。对补体分子的过度活化具有抑制和调节作用，在防治补体介导的缺血再灌注损伤以及异种器官移植超急性排斥反应等疾病中具有广阔的应用前景。本文主要综述CR1的结构功能及生物学活性，sCR1基因的克隆与表达及在创伤、缺血再灌注损伤中的应用研究现状。

    关键词: 补体;受体;生物学活性;基因;克隆

    Structure and function of CR1and proposal of cloning and high-level expression of sCR1

    LUO Xue，WANG Zheng-qing

    (Department of Microbiology，Third Military Medical University，Chongqing 400038，China)

    Abstract: Complement receptor type1shows endogenous and exogenous activity，which can deactivate the C3.C5convertase on not-self and self cytomembrane.CR1has activation to the three pathways of complement activation to enhance decay of the C3.C5convertase and helps factor1to split C3b and C4b.Because of its inhibition and adjustment to over-acti-vation of complement，it has good future to be used in prevention and cure of ischemical reperfusion injury and xeno-organ transplantation.This article mainly overviewed the structure and function of CR1and proposal of cloning and high-level ex- ......