【摘要】 目的 观察中药抗纤灵颗粒对大鼠试验性慢性肾衰的药效作用，探讨此方改善肾小球硬化、肾间质纤维化的机制。方法 设立对照组、模型组、抗纤灵组、大黄组、丹参组共5组。服药30天。采用SPSS分析，血肌酐(Scr)、血尿素氮(BUN)用药治疗前后指标及胆固醇(CHL)、甘油三酯(TG)，各组间指标的变化和进行肾脏组织形态学观察。结果 模型与抗纤灵组比较：Scr、BUN指标明显降低(P<0.05)，各治疗组间的比较：抗纤灵组Scr、BUN指标均低于丹参组和大黄组。TG抗纤灵组与模型组比较，P<0.05。肾组织形态可见：抗纤灵组肾衰大鼠肾小球萎缩明显减轻，机构较接近正常。结论 抗纤灵颗粒对改善试验性慢性肾衰有较明显的药效作用。

    【关键词】 抗纤灵颗粒； 动物实验； 慢性肾炎； 肾间质纤维化

    Research about animal experiment of Kang Xian Ling Ke Li (KXLKL) on chronic renal failure in pharmacodynamics

    HOU Wei-guo，TU Li-qun，HE Li-qun，et al.

    Department of Nephrology，Shuguang Hospital Attached to Shanghai University of TCM，Shanghai 200021，China

    【Abstract】 Objective To observe the effect of pharmacodynamics of KXLKL on chronic renal failure in experimental rats and investigate the mechanism of its improvement of glomerulosclerosis and renal interstitial fibrosis. Methods Rats were randomly divided into control，model，KXLKL，Da Huang and Dan Shen(group) which were administrated for 30 days respectively. Analysis of SPSS adopted，Scr，BUN，serum cholesterol ......