2型受体_____血管紧张素Ⅱ；2型受体；肾皮质；衰老

血管紧张素及其2型受体在大鼠肾脏中表达的增龄性变化

http://www.100md.com 《第四军医大学学报》 2005年第9期

2型受体,,血管紧张素Ⅱ；2型受体；肾皮质；衰老,1材料和方法,2结果,3讨论,【参考文献】

     Expressions of angiotensin Ⅱ and its subtype 2 receptor in aging progress of rat kidney

    GUO Ning, BAO Gang, JIANG Xin

    Department of Cardiology, First Hospital, Xian Jiaotong University, Xian 710061, China

    【Abstract】 AIM: To investigate the expressions of angiotensin Ⅱ (AngⅡ) and its subtype 2 receptor (AT2) in the aging progress of rat kidney, especially in gerontic rats. METHODS: RTPCR was used to observe the expressions of AT2 mRNA in the cortex of rat kidney, including neonate rats (1 d), mature rats (8 weeks) and gerontic rats (20 months). AngⅡ was detected in the three groups. RESULTS: The expression level of AT2 mRNA in the cortex of neonate rats (0.85±0.07) was higher, but that in cortex of mature (0.29±0.05) and gerontic (0.32±0.04) rats was lower (P<0.05). AngⅡ level (ng/g) in neonate (2092±153) and mature (2125±107) rats was higher than that in gerontic rats (1876±80, P<0.05). CONCLUSION: These results suggest that the decrease of AT2 mRNA may be involved in the progress of kidney aging. ......

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