摘要: 核因子-κB(nuclear factor-kappa B，NF-κB)在炎性及免疫反应中起着重要的作用，创伤性脑损伤后NF-κ表达已在实验动物及临床观察中得到肯定，但对伤后NF-κB的作用仍存在不同的争议。NF-κB活化的机制目前仍不十分清楚。笔者就近年来创伤性脑损伤后NF-κB的研究进行如下综述，着重阐明脑损伤后NF-κB活化的变化机制及其双重作用性。

    关键词: 脑损伤;核因子-κB;神经损伤;神经保护

    Neuro-damage and cytoprotection of NF-κB after traumatic brain injury

    GENG Ming-ying，CHENGYuan

    (Department of Neurosurgery，Second Affiliated Hospital of Chongqing University of Medical Sciences，Chongqing 400010，China)

    Abstract: NF-κB is widely known for its key roles in inflammation and immune responses.Incidence of increased NF-κB after traumatic brain injury(TBI)has been observed both in animals and patients，but there is still different views about the function of NF-κB after TBI.The mechanism of NF-κB activation is still not clear.The author summarized the status of recent studies on NF-κB after TBI stressing on the mechanism of the changes and the double function of neuro-damage and cytoprotection.

    Key words:traumatic brain injury(TBI);NF-κB

    颅脑损伤后的脑水肿是导致脑外伤病人死亡和伤残的重要原因之一。脑水肿从本质上说是一种炎症现象。近年对炎症本质的研究取得了较大进展，发现炎症的发生与核转录因子有关，特别是NF-κB起了关键性作用 ......