肝硬化__(期刊论文)

JNK信号通路对乙醛刺激的大鼠肝星状细胞增殖的影响

http://www.100md.com 《第四军医大学学报》 2005年第10期

肝硬化,,肝硬化；肝星状细胞；cJun氨基末端激酶；SP600125；细胞分裂,1材料和方法,2结果,3讨论,【参考文献】

     Effects of JNK on proliferation of acetaldehyde stimulated hepatic stellate cells in rats

    ZHONG XianFei,JIANG MingDe,MA HongDe,ZENG WeiZheng,LI XiaoAn

    Department of Gastroenterology,General Hospital，Chengdu Military Command,Chengdu 610083,China

    【Abstract】 AIM: To explore the regulating mechanism of cJun Nterminal kinase (JNK) signal transduction in the proliferation of hepatic stellate cells stimulated by acetaldehyde.METHODS: Rat hepatic stellate cells (HSCs) stimulated by acetaldehyde were incubated with different concentration of SP600125 in vitro.The cell proliferation was evaluated by MTT colorimetric assay and the variability of JNK was examined by Western Blotting.RESULTS: SP600125 at different concentrations (20 ng/mL,60 ng/mL and 100 ng/mL) suppressed the activity of JNK{MVI [(360±34),(242±18),(32±09)] vs (476±86),P<005}，but also inhibited the proliferation of HSCs stimulated by acetaldehyde in a dosedependent manner [Optical density(A): (013±001),(012±001),(012±001)，P<005].CONCLUSION: The proliferation inhibition of HSCs is correlated with the decreased activity of JNK. ......

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