Lysisin aspirin protects against gentamicin ototoxicity

    GUO Shuª²Yun1, SUN Xiaoª²Li1, HUANG Weiª²Guo2, LIU Shunª²Li2

    1Department of Chemistry, School of Basic Medicine, 2Department of Otorhinolaryngology, Xijing Hospital, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To study the prevention of gentamicin ototoxicity by lysisin aspirin in guinea pigs. METHODS: Fortyª²eight guinea pigs were divided into 4 groups with 12 each: gentamicin treated group (GM), Lysisin aspirin treated group (LAP), GM+LAP group and control group. Auditory brainstem response and cochlear preparation transmission electron microscope were used to evaluate the effects of hair cells on hearing threshold and the morphology of hair cells. Serum levels of GM were also tested. RESULTS: GM group developed a progressive threshold shift, reaching 50 dB at 8 kHz and the threshold shift in GM+LAP group was 30 dB (P<0.05). Injury in high frequency was significantly more severe than that in low frequency (P<0.01). Morphological results were consistent with the functional results. LAP did not affect serum levels of GM. CONCLUSION: The results suggest that LAP may be a promising therapeutic agent in reducing gentamicin ototoxicity. ......