摘要: 目的 建立一种伤情稳定、满足实验需要的颅脑合并胸部撞击伤动物模型，并探讨损伤早期血浆IL-6、IL-10含量变化及意义。 方法 采用自行研制的小型生物撞击机，选择合适的撞击参数制作大鼠颅脑合并胸部撞击伤动物模型;酶联免疫法动态检测伤后血浆IL-6、IL-10含量变化。 结果 成功建立了大鼠颅脑合并胸部撞击伤动物模型;伤后早期IL-6、IL-10含量显著升高，伤后6、24、72小时的含量分别为(511.81±65.68)pg.ml、(103.36±9.45)pg.ml;(322.16±33.08)pg.ml、(79.23±10.26)pg.ml;(138.05±68.75)pg.ml、(49.28±6.21)pg.ml。 结论 本动物模型伤情稳定、重复性好，能满足多发伤实验研究需要;伤后早期血浆IL-6、IL-10含量升高，在炎症反应和继发性损伤的发生过程中起重要作用，其含量变化与伤情严重程度密切相关。

    关键词: 脑损伤;胸部损伤;撞击伤;细胞因子

    Changes and significance of plasma IL-6、IL-10content after rat brain and thoracic impact injury

    XUMin-hui，YU Jun，LIU Bao-song

    (Department of Neurosurgery，Institute of Surgery Research，Daping Hospital，Third Military Medical University，Chongqing 400042，China)

    Abstract: Objective To establish a brain and thorax impact injury animal model with injury having stable degree to fit for the needs of experiment，and study the variation and meaning of plasma IL-6、IL-10content early after the injury.Methods Self-made animal impact injury minimachine with suitable parameters was used to establish the brain and thorax impact injury animal model.Plasma IL-6、IL-10contentwas measured by ELISA.Results Brain and thorax impact inju-ry model was successfully established.Plasma IL-6、IL-10increased significantly early after injury.They were(511.81±65.68)pg.ml ......