[摘要] 目的 应用化学发光等技术，研究正常糖耐量人中正常体质量者及超重/肥胖者胰岛素敏感性的异同，以及体脂含量及分布与胰岛素敏感性的关系。方法 对30例居住青岛地区中国人进行化学发光法测定胰岛素及C肽，并应用核磁共振技术(MRI)测定局部体脂。结果 ①超重/肥胖组较之正常体质量组胰岛素介导的葡萄糖利用率明显降低(P<0.01)，以糖原合成障碍为主(P<0.01)。②局部体脂中以腹内脂肪增加对胰岛素敏感性的影响最为显著(r=-0.80，P<0.01)。结论 中国人正常糖耐量、超重/肥胖个体胰岛素敏感性下降，腹内脂肪增加是胰岛素抵抗的主要原因。

    [关键词] 化学发光技术;胰岛素敏感性;体脂含量;局部体脂

    Study on relation between insulin resistance and distribution of body fat in obese individuals

    TAO Lu ，XU Xiao-wei，HAN Xian-qi

    (1.Haici Hospital of Qingdao，Qingdao266033，Shandong，China;2.Jimo People's Hospital，Jimo266098，Shandong，China)

    Abstract:Objective It is to study the similarities and differences of insulin sensitivity in normal body mass and over-weight/obese individuals among normal sugar tolerance persons and the relation of body fat content and distribution with in-sulin sensitivity using chemiluminescence.Methods Insulin and C peptide in thirty Chinese resided in Qingdao area were men-surated with chemiluminescence ......