【摘要】 目的 探索卵巢癌发病的危险因素和保护因素，为预防卵巢癌发病提供依据。 方法 采用病例对照研究方法，病例选自2000年7月～2005年4月某省级医院被确诊为卵巢癌的住院患者229名，366名对照来自同一医院确诊的外伤患者。用卵巢癌危险因素流行病学调查问卷，对病例与对照的病历进行查询。对所得资料进行单因素和多因素非条件logistic回归分析。 结果 单因素分析显示，子宫肌瘤、痛经、一级亲属肿瘤史、初潮年龄、行经期、月经周期、肿瘤史和累计结婚年数等是卵巢癌的危险因素，共妊娠数、自然流产数、人工流产数等是卵巢癌的保护因素。多因素分析显示，与卵巢癌发生关联显著的因素是共妊娠数、人工流产数、初潮年龄、行经期和月经周期。 结论 卵巢癌的发病是多因素共同参与的结果。

    【关键词】 病例对照研究;危险因素;卵巢肿瘤

    A case-control study on risk factors of ovarian cancer

    WU Wei ，HE Miao ，WANG Jin-ting ，DAI Xiao-chun ，GONG Wei ，ZHOU Bao-sen .

    Department of Epidemiology，China Medical Uni-versity，Shenyang 110001，China;Computer Office，The First Affiliated Hospital of China Medical University，Shenyang 110001，China;Cancer Institute，The First Affiliated Hospital of China Medical University，Shenyang 110001，China

    【Abstract】 Objective To study the risk factors and protective factors of ovarian cancer，and to pro-vide basis for preventing ovarian cancer.Methods Case-control study was carried out among229pa-tients with ovarian cancer and336controls with trawnatism in a certain province hospital from2000July to2005April.Questionnaire was used to investigate risk factors of ovarian cancer among cases and con-trols.Results Univariate analysis indicated that the uterus tumor ......