Correlation analysis of serum uric acid and carotid atherosclerosis in type 2 diabetes mellitus

    WANG Li,ZHANG Nanª²Yan,CHEN Fei,ZHAO Kuiª²Yan,SUN Huiª²Hui,MENG Fanª²Jiang,LI Xiaoª²Miao,JI Qiuª²He

    Department of Endocrinology,Xijing Hospital,Fourth Military Medical University,Xi¬ðan 710033,China

    ¡¾Abstract¡¿ AIM: To determine whether uric acid concentration is an independent factor associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM).METHODS: A crossª²sectional study of 318 T2DM patients with or without carotid atherosclerosis was conducted.Uric acid and other T2DM risk factors,including age,T2DM duration,bodyª²mass index (BMI),free blood glucose (FBG),systolic blood pressure (SBP),diastolic blood pressure (DBP),serum cholesterol (TC),triglyceride (TG),and blood white cells (WBCs),were analyzed.RESULTS: In Logistic regression analysis of carotid atherosclerosis,uric acid (P<0ª±001) was higher in carotid atherosclerosis group.Uric acid,together with age(P=0ª±001) and SBP (P<0ª±05),was associated with carotid atherosclerosis in T2DM.After adjustment of kidney function by uric acid /creatinine ratio,the difference disappeared.In multiple regression analysis of uric acid in all the groups,creatinine (P<0ª±001),carotid atherosclerosis(P<0ª±001),BMI(P=0ª±004) and WBCs(P=0ª±001) were independent determinants.CONCLUSION: Uric acid is an independent factor in T2DM with carotid atherosclerosis.The increased level may be associated with the injury of kidney function. ......