孤啡肽对大鼠体内外结肠动力的影响
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李海燕, 李得香, 严 祥, 彭淑英, 崔 琳,
孤啡肽;阿片;肌张力;结肠动力;肠神经系统李海燕,李得香,严祥,彭淑英,崔琳,曹菊梅.孤啡肽对大鼠体内外结肠动力的影响.世界华人消化杂志2006;14(14)1377-1381,孤啡肽对大鼠体内外结肠
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李海燕, 彭淑英, 崔琳, 曹菊梅, 甘肃省金川集团公司医院消化科 甘肃省金昌市 737100
严祥, 甘肃省兰州大学第一医院老年病科 甘肃省兰州市 730000
李得香, 甘肃省金昌市第二人民医院, 甘肃省金昌市 737100
李海燕, 2005年兰州大学硕士, 主治医师, 主要从事胃肠动力的研究.
通讯作者: 李海燕, 737100, 甘肃省金川集团公司医院消化科. lihaiyan99@tom.com
电话: 0935-3628668 传真: 0935-8811453
收稿日期: 2006-03-12 接受日期: 2006-03-24
Effects of orphanin FQ on colonic motility of rats
Hai-Yan Li, De-Xiang Li, Xiang Yan, Shu-Ying Peng, Lin Cui, Ju-Mei Cao
Hai-Yan Li, Shu-Ying Peng, Lin Cui, Ju-Mei Cao, Department of Gastroenterology, the Affiliated Hospital of Jinchuan Corporation Company, Jinchang 737100, Gansu Province, China
De-Xiang Li, Department of Clinic, the First Hospital of Jinchang City, Jinchang 737100, Gansu Province, China.
Xiang Yan, Department of Geriatrics, 1st Affiliated Hospital of Lanzhou University, Lanzhou 730000, China
Correspondence to: Dr. Hai-Yan Li, Department of Gastroenterology, the Affiliated Hospital of Jinchuan Corporation Company, Jinchang 737100, Gansu Province, China. lihaiyan99@tom.com
Received: 2006-03-12 Accepted: 2006-03-24
Abstract
AIM: To investigate the role of ORL1 (opioid receptor-like 1) receptor in the colon movement.
METHODS: The test for tension of colonic muscle strips in vitro and the colonic myoelectrical activity in vivo as well as the charcoal suspension pushing test were performed to evaluate the effect of orphanin FQ (OFQ) on the motility of colon.
RESULTS: NOFQ (1-1000 nmol/L) caused an immediate tonic contraction in the isolated colon in a concentration-dependent manner. In anesthetized rats, intravenous administration of OFQ (1 mg/kg) caused phasic contractions in the proximal colon (t = 2.41, P = 0.02), and this contraction was not inhibited by classical opioid receptor antagonist, naloxone. Subcutaneous administration of OFQ (3 nmol/kg) accelerated the colonic transit of charcoal suspension in vivo (48 ......
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