食管癌组织环氧化酶-2的表达与血管生成的关系
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产松苗, 欧希龙, 孙为豪, 陈国胜, 颜 芳,
环氧化酶-2;食管肿瘤;血管生成;微血管密度;免疫组织化学产松苗,欧希龙,孙为豪,陈国胜,颜芳,邵耘,许海尘,薛绮萍.食管癌组织环氧化酶-2的表达与血管生成的关系. 世界华人消化杂志200
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产松苗, 欧希龙, 陈国胜, 颜芳, 东南大学临床医学院附属中大医院消化科 江苏省南京市 210009
孙为豪, 邵耘, 许海尘, 薛绮萍, 南京医科大学第一附属医院老年医学科 江苏省南京市 210029
产松苗, 1996年河北医科大学毕业, 东南大学临床医学院2003级研究生, 主要从事消化系肿瘤的血管形成及其干预机制方面的研究.
通讯作者: 孙为豪, 210029, 江苏省南京市, 南京医科大学第一附属医院老年医学科. weihaosun@hotmial.com
收稿日期: 2006-04-22 接受日期: 2006-05-08
Expression of cyclooxygenase-2 in esophageal carcinoma and its correlation with angiogenesis
Song-Miao Chan, Xi-Long Ou, Wei-Hao Sun, Guo-Sheng Chen, Fang Yan, Yun Shao, Hai-Chen Xu, Qi-Ping Xue
Song-Miao Chan, Xi-Long Ou, Guo-Sheng Chen, Fang Yan, Department of Gastroenterology, the Affiliated Zhongda Hospital of Southeast University Clinical Medical College, Nanjing 210009, Jiangsu Province, China
Wei-Hao Sun, Yun Shao, Hai-Chen Xu, Qi-Ping Xue, Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Correspondence to: Wei-Hao Sun, Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. weihaosun@hotmial.com
Received: 2006-04-22 Accepted: 2006-05-08
Abstract
AIM: To investigate the expression of cyclooxygenase-2 (COX-2) and its correlation with the angiogenesis and clinicopathological features in esophageal carcinoma.
METHODS: Ninety tumor specimens resected from patients with squamous cell carcinoma of the esophagus were obtained, and 34 corresponding paracancerous normal tissues were randomly selected as the controls. Immunohistochemical staining was used to detect the expression of COX-2. Monoclonal antiboty against CD34 was used for displaying vascular endothelial cells, and microvascular density (MVD) was determined by counting the CD34-positive cells. The correlations of COX-2 expression with MVD and clinicopathological parameters of the patients were analyzed.
RESULTS: The positive rates of COX-2 and MVD expression in the cancerous tissue were 84 ......
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