四氯化碳诱导兔肝硬化模型的动态研究
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李 栋, 张乐玲, 侯怀水, 时 庆, 沈柏均
四氯化碳;肝硬化模型;兔李栋,张乐玲,侯怀水,时庆,沈柏均.四氯化碳诱导兔肝硬化模型的动态研究. 世界华人消化杂志2006;14(14)1403-1407 兔肝大体标本.AHe
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李栋, 侯怀水, 时庆, 沈柏均, 山东大学齐鲁医院低温医学研究室 山东省济南市 250012
张乐玲, 山东大学齐鲁儿童医院内科 山东省济南市 250022国家自然科学基金项目, No. 30271248
通讯作者: 沈柏均, 250012, 山东省济南市文化西路107号, 山东大学齐鲁医院低温医学研究室. shenbaijun@21cn.com
电话: 0531-82169215 传真: 0531-86900909
收稿日期: 2006-03-10 接受日期: 2006-04-06
Dynamic changes of liver in cirrhosis model of rabbits
Dong Li, Le-Ling Zhang, Huai-Shui Hou, Qing Shi, Bai-Jun Shen
Dong Li, Huai-Shui Hou, Qing Shi, Bai-Jun Shen, Laboratory of Cryomedicine, Qilu Hospital, Shandong University, Ji’nan, 250012, Shandong Province, China
Le-Ling Zhang, Department of Internal Medicine, Qilu Children’s Hospital, Shandong University, Ji’nan, 250022, Shandong Province, China
Supported by National Natural Science Foundation of China, No. 30271248
Correspondence to: Bai-Jun Shen, Laboratory of Cryomedicine, Qilu Hospital, Shandong University, 107 Wenhua West Road, Ji’nan 250022, Shandong Province, China. Shenbaijun@21cn.com
Received: 2006-03-10 Accepted: 2006-04-06
Abstract
AIM: To establish a relatively simple and feasible rabbit model of liver cirrhosis and analyze the dynamic changes of function and histopathology of cirrhotic liver.
METHODS: Twenty-four New Zealand rabbits were divided into two groups, of which twenty were received subcutaneous injection of carbon tetrachloride (CCl4) along with gastric infusion of edible ethanol for eight weeks. Animals in control group were fed with regular water and injected subcutaneously with the same quantity of olive oil. The development of hepatic fibrosis was recorded by Masson’s trichrome method fortnightly. Blood samples were collected to measure the blood protein and enzymes fortnightly.
RESULTS: After treatment with CCl4, hepatic fibrosis was aggravated with time went by. As compared with those in normal controls, the levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the experimental groups were increased significantly (AST: 983 ......
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