摘要 为探讨病毒性肝炎多重感染的危害，本研究将388例乙型肝炎多重感染与420例单纯性乙型肝炎作了临床特征比较分析。结果表明，与单纯性乙型肝炎相比，乙型肝炎多重感染组性别及年龄分布与之相似，均以男性青壮年为主。在临床表现上，乙型肝炎多重感染组较乙型肝炎组重症肝炎及肝硬化比重大，黄疸发生率高，谷丙转氨酶(ALT)、血清总胆红素(BILT)、血清直接胆红素(BILD)、血清间接胆红素(BILI)等肝功能指标高，平均住院天数长。说明乙肝多重感染较单纯性乙型肝炎病情重，对肝脏损害大，对预后有一定影响。

    关键词 乙型病毒性肝炎；多重感染；临床症状；生化指标

    Clinical Features of Multiple Hepatitis Virus Infections

    LI Yan,ZHANG Guanqun,WANG Baoguo,YANG Yi,CHENG Sidong,WU Biwen

    (Guangdong College of Pharmacy,Guangzhou,P.R.China 510224)

    Abstract In order to study the clinical features of multiple hapatitis virus infections, the clinical characteristics of 388 patients with superinfection of HBV were compared with 420 patients with HBV infection alone. The results showed that the multiple infection group and the HBV infection group had no significant difference in the distribution of sex and age,with the majority of young males. With respect to the clinical manifestation, the multiple infection group had more fulminant hepatitis and cirrhosis than the HBV infection group with statistically significant difference. The incidence of jaundice was significantly higher in multiple infection group than that in HBV infection group. Serum alnini aminotransferase(ALT),serum total bilirubin(BILT) ,serum direct bilirubin(BILD) and serum inderect bilirubin(BILI) were also significantly higher in multiple infection group than that in the HBV infection group. The hospitalizing time was significantly longer in patients with multiple infections. The results suggest that multiple hepatitis virus infections cause more severe damage to the liver,result in prolonged course and poorer prognosis than those with HBV infection alone. ......