【摘要】 目的 探讨丁螺环酮与帕罗西汀联合治疗抑郁症的疗效。方法 符合ICD-10或CCMD-3抑郁症诊断标准的门诊和住院病人79例，随机分成两组，分别用丁螺环酮联合帕罗西汀和单用帕罗西汀治疗6周，采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效，用副反应量表(TESS)评定副反应。结果 6周末联合组HAMD和HAMA评分低于单用组。在第2周末、第6周末联合组的HAMD和HAMA的平均减分率高于单用组。两组间的副反应情况相仿。结论 丁螺环酮联合帕罗西汀治疗抑郁症的疗效优于单用帕罗西汀。

    【关键词】 丁螺环酮；帕罗西汀；抑郁症

    A comparative study of buspirone combined paroxetine in treatment of depression

    LIN Zhao-wu, SUN Guo-ping.Qingdao Mental Health Center, Shandong 266034，China

    【Abstract】 Objective To study the efficacy of buspirone combined paroxetine on depression.Methods 79 cases of outpatients and inpatients with the depression diagnosed according to ICD-10 or CCMD-3 were divided into two groups randomly. The two groups were treated with buspirone combined paroxetine and single paroxetine respectively for six weeks. The efficacy was measured with Hamiltion Depression Scale (HAMD) and Hamiltion Anxiety Scale (HAMA). The side effects were assessed by the Treatment Emergent Symptom Scale(TESS).Results The therapeutic efficacy in buspirone combined paroxetine therapy group was significantly lower than than that single paroxetine group on six weekend. The reduce rate of mean score of HAMA and HAMD in combined group was significantly higher than that of single group. Two groups of side effects was similar.Conclusion Buspirone combined paroxetine therapy has better effect in treatment of depression. ......