【摘要】 目的 观察甘草水提液对吸烟小鼠肺损伤的保护作用。方法 昆明种小鼠，随机分成3组，即正常对照组、吸烟模型组、甘草水提液组。正常对照组小鼠不吸烟，其余二组连续吸烟60天、4次/d、30min/次，甘草水提液组每天2次给予甘草水提液灌胃，其余两组每天2次给予蒸馏水灌胃对照，60天后处死动物，取左上肺固定，石蜡包埋，切片HE染色观察，其余肺组织做成匀浆，检测肺组织匀浆中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量。结果 吸烟组小鼠肺内出现程度不等的慢性支气管炎及肺气肿，同时肺部SOD活性明显下降，MDA含量明显增加。吸烟后加服甘草水提液组小鼠肺部病理表现明显减轻，肺部的SOD活性增加，MDA含量下降。结论 甘草水提液对小鼠长期吸烟所造成的支气管肺组织病理损害有保护作用，其作用机制可能与甘草在肺部发挥的抗氧化作用等作用有关。

    【关键词】 甘草；吸烟；肺损伤；超氧化物歧化酶(SOD)；丙二醛(MDA)

    The protecive effects of glycyrrhizae on smoke induced pulmonary injury mousemodels

    ZHEN Zhi-dong,QIN Dong-yun, WU Tie.

    Dept of Pharmacology ,Guangdong Medical College ,Zhanjiang 524023，China

    【Abstract】 Objective To investigate the Protective effects of glycyrrhizae water-extraction on smoke induced Pulmonavy injury mousu mudels.Methods 60 Kunwing mice of 3mouths were randomly divided into 3 groups:healthy control group ,model group and glycyrrhizae group .those mouse of model group and glycyrrhizae group were exposed to cigarette smoke ,qid,30 minute /day for 60 days At the same time ,those mouse of glycyrrhizae group were given glycyrrhizae water-extraction ,Bid for 60 days ,the other mouse were given distilled water ,Bid for 60days. The pathologil changes of rirways and lung tissues were determined .The level of serum lipid Peroxidation Product malondialdehyde(MDA) and the activity of blood superoxide dismutase(SOD) were measured.Results Therewere more chronic bronchitis and emphysema in the model group than in the healthy control .group Cigarette smoking reduced the activity of SOD and increased MDA level .Compared with the model group, the pathologic injury of airways and lung tissues wete reduced, the activity of SOD increased and the level of MDA recreased .in glycyrrhizae group.Conclusion There are protective effects of dlycyrrhizae waeter-extraction on smoke induced pulmonary injury.The mechauism may due to its anti oxidation. ......