头孢克罗缓释片的制备及体外释药试验方法考察
头孢克罗,,头孢克罗；缓释片；羟丙基甲基纤维素(HPMC)；体外释药试验；方法,1实验部分,2结果与讨论,3结论,参考文献
摘要 以羟丙基甲基纤维素为骨架制备了水凝胶型头孢克罗缓释片，以体外释药试验筛选处方，制得的缓释片体外释药规律符合Higuchi方程。同时考察了不同的试验方法对头孢克罗缓释片体外释药的影响，为进一步进行释药影响因素考察打下基础。关键词 头孢克罗；缓释片；羟丙基甲基纤维素(HPMC)；体外释药试验；方法
Preparation of Cefaclor Sustained Release Tablet and Study of the Method for in vitro Drug Release Test
LI Xiao_fang,JIN Miao_zhen,LIN Hua_qing,ZHAO Dui, CHEN Shao_qin
(Guangdong College of Pharmacy, Guangzhou, P.R.China 510224 )
Abstract Cefaclor sustained_release tablet was prepared using Hydroxypropyl_methylcellulose (HPMC) as hydrophilic matrix.The in vitro release characteristics of cefaclor from the tablet appeared to follow Higuchi_kinetics. The effect of different drug release test methods on cefaclor release rate from the matrix tablet was observed.
Key Words cefaclor; HPMC; sustained release tablet; in vitro drug release test method.
头孢克罗是由美国Lilly公司首先研究开发的第二代头孢菌素类抗生素 ......
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