硬化性血管瘤_____](期刊论文)

肺硬化性血管瘤的临床病理特点

http://www.100md.com 《实用医技杂志》 2006年第4期

硬化性血管瘤,,],肺；硬化性血管瘤；临床病理学；免疫组织化学；TTF1,1材料与方法,2结果,3讨论,参考文献：

     [关键词] 肺；硬化性血管瘤；临床病理学；免疫组织化学；TTF1

    [摘要] 目的：探讨肺硬化性血管瘤的临床病理特点及组织来源。方法：对4例肺硬化性血管瘤进行临床病理、免疫组化研究。结果：肺硬化性血管瘤由实性片块区、乳头区、血管瘤样区及硬化区组成。被覆乳头表面、实性区裂隙及血管样腔面的立方细胞；实性区及乳头轴心为形态一致的圆形、多边形胞浆浅染细胞。免疫组化示：两种细胞均表达TTF1，立方细胞表达CK、EMA；而浅染圆形细胞弥漫表达Vimentin、ER、PR，部分表达NSE和Syn。结论：肺硬化性血管瘤可能起源于肺泡Ⅱ型细胞或呼吸道的原始的多潜能干细胞。ER、PR的高表达可能与女性的高发病率密切相关。

    Clinicopathological Characteristics of Sclerosing Hemangioma of the Lung

    YANG Guoyi,XIA Yuhong,HONG Jiangang,et al

    (Wuxi No.5 People's Hospital,Wuxi， Jiangsu 214073，China)

    Abstract：Objective To study the clinicopathological characteristics and histogenesis of sclerosing hemangioma of the lung (SHL).Methods Four cases of SHL were investigeted by light microscopy and immunohistochemistry.Results The tumor showed a mixture of the following four histological patterns,solid,papillary,hemangiomalike and sclerotic.Cuboidal cells covered the papillary projections and cleftslide spaces in solid areas whereas solid areas and the stalk of papillary projections were composed of uniform,round or polygonal pale cells.Immunohistochemistry staining revealed that the surface of the cuboidal cells expressed TTF1 ......

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