尼卡地平_____](期刊论文)

两药合用控制性降压对鼻内镜手术中术野质量的改善作用

http://www.100md.com 《实用医技杂志》 2006年第5期

尼卡地平,,],尼卡地平，艾司洛尔；鼻内镜术；控制性降压；术野,1资料与方法,2结果,3讨论,参考文献：

     [摘要] 目的：比较单独应用尼卡地平和尼卡地平复合艾司洛尔控制性降压在鼻内镜术中的术野质量。方法：40例行鼻内窥镜手术患者，随机分成尼卡地平组(N组，n=20)和尼卡地平复合艾司洛尔组(NE组，n=20)，两组分别用尼卡地平和尼卡地平、艾司洛控制性降压，平均动脉压控制在55 mmHg~60 mmHg之间，记录降压前后MAP、HR变化以及术中出血量、手术时间，对术野质量进行评分。结果：与降压前MAP比较，N组在停药后各时点明显降低(P<0.01)，NE组在停药10 min显著低于降压前(P<0.01)，NE组在停药20 min、30 min与N组同期比较明显升高(P<0.01)；与降压前HR比较，N组在降压期间显著增快(P<0.05)，NE组在降压期间及停药10 min与N组同期比较显著减慢(P<0.01)；NE组术中各时间点术野质量评分及尼卡地平用量明显低于N组(P<0.01)。结论:尼卡地平复合艾司洛尔用于鼻内镜术中控制性降压可明显改善术野质量，提高手术效率，可能与控制心率有密切关系。同时有血压波动小、可控性好、停药后血压回升较快等优点，比单独应用尼卡地平效果更佳。

    [关键词] 尼卡地平，艾司洛尔；鼻内镜术；控制性降压；术野

    Improvemnt of Nicardipine Combined with Esmolol on Surgery Field During Controlled Hypotension of Anesthesia in Endoscopic Sinus Surgery

    WU Chunsheng1,LI Zhenhua2,LIANG Chunqi1,et al

    (1.Xiangxi Prefecture People's Hospital,Jishou,Hunan 416000,China;

    2.Gongming Hospital,Baoan Region,Shenzhen，Guangdong 518106,China)

    Abstract:Objective The study was designed to evaluate the quality of surgery field between single nicardipine and nicardipine combined with esmolol during controlled hypotension of anesthesia in endoscopic sinus surgery(ESS).Methods Forty ASA ⅠⅡ patients underwent ESS were randomly divided into nicardipine group(group N, n=20) and nicardipine combined with esmolol group(group NE, n=20),two group used respectively nicardipine and nicardipine、esmolol to control hypotension,MAP and heart rate(HR) were recorded after controlled hypotension,bleeding volume、nicardipine dosage ......

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