胃肠道恶性肿瘤Cyclins表达分型与MDR1及TNM分期的关系
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郭 勇, 覃吉超, 周 毅, 何小军, 李伟华,
Cyclins;细胞周期;多药耐药基因1;胃肠道恶性肿瘤;TNM分期;流式细胞术,郭勇,覃吉超,周毅,何小军,李伟华,谢大兴,龚建平
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郭勇, 覃吉超, 周毅, 何小军, 李伟华, 谢大兴, 龚建平, 华中科技大学同济医学院附属同济医院分子医学中心 湖北省武汉市 430030
卫生部临床学科重点资助项目, No. 20012537
973肿瘤计划资助项目, 2004CB518705
通讯作者: 龚建平, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院分子医学中心. gongjianping11@hotmail.com
电话: 027-83663301
收稿日期: 2006-02-28 接受日期: 2006-03-28
Correlations of Cyclins expression types with multi-drug resistance-1 and TNM staging in gastrointestinal cancer
Yong Guo, Ji-Chao Qin, Yi Zhou, Xiao-Jun He, Wei-Hua Li, Da-Xing Xie, Jian-Ping Gong
Yong Guo, Ji-Chao Qin, Yi Zhou, Xiao-Jun He, Wei-Hua Li, Da-Xing Xie, Jian-Ping Gong, Center of Molecular Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Supported by Emphasized Project from Clinical Department of Ministry of Health, No. 20012537, and the Tumor Project in 973 Plan, No. 2004CB518705
Correspondence to: Professor Jian-Ping Gong, Center of Molecular Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. gongjianping11@hotmail.com
Received: 2006-02-28 Accepted: 2006-03-28
Abstract
AIM: To investigate the expression of four Cyclins in gastrointestinal cancers, and to explore their correlations with multi-drug resistance-1 (MDR1) and TNM staging.
METHODS: Sixty-two fresh samples (gastric cancer 32, colorectal cancer 30) from patients underwent operation were collected, and the expression of Cyclin (D1, E, A, B1) and MDR1 were detected by flow cytometry. In addition, pathological reports were analyzed for TNM staging.
RESULTS: According to the expression of four Cyclins, four cell cycle types were divided in the gastrointestinal cancers. These four cell cycle types were in accordance with TNM staging (κ = 0.599, P < 0.01) and marked correlation with the level of MDR1 expression (rs = 0 ......
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