一种新的幽门螺杆菌克拉霉素耐药相关基因
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姜 葵, 何利华, 赵 飞, 王邦茂, 张建中
幽门螺杆菌;克拉霉素;耐药,姜葵,何利华,赵飞,张建中,姜葵,王邦茂,姜葵,通讯作者,Anovelgeneassociatedwithclarithromyci
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姜葵, 何利华, 赵飞, 张建中, 中国疾病预防控制中心传染病预防控制所诊断室 北京市 102206
姜葵, 王邦茂, 天津医科大学总医院消化科 天津市 300052
姜葵, 2004年中国疾病预防控制中心传染病预防控制所博士生, 副主任医师, 主要从事幽门螺杆菌耐药机制的研究.
天津市高等学校科技发展基金资助项目, No. 20050233
通讯作者: 张建中, 102206, 北京市, 中国疾病预防控制中心传染病预防控制所诊断室. zhangjianzhong@icdc.cn
电话: 010-61739456
收稿日期: 2006-04-11 接受日期: 2006-04-18
A novel gene associated with clarithromycin resistance of Helicobacter pylori
Kui Jiang, Li-Hua He, Fei Zhao, Bang-Mao Wang, Jian-Zhong Zhang
Kui Jiang, Li-Hua He, Fei Zhao, Jian-Zhong Zhang, National Institute of Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Kui Jiang, Bang-Mao Wang, Department of Gastroenterology, General Hospital, Tianjin Medical University, Tianjin 300052, China
Supported by University Science and Technology Development Foundation of Tianjin, No. 20050233
Correspondence to: Professor Jian-Zhong Zhang, National Institute of Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, P.O. Box 5, Changping, Beijing 102206, China. zhangjianzhong@icdc.cn
Received: 2006-04-11 Accepted: 2006-04-18
Abstract
AIM: To investigate the mechanism of H pylori resistance to clarithromycin in different concen-trations, and to look for a novel gene associated with clarithromycin resistance.
METHODS: H pylori 26695 were used as the primary strain. Antibiotic selection pressure test, mutation by transponson (Tn5) containing chloromycetin marker and E-test were performed for the analysis of H pylori resistance to clarithromycin in different concentrations.
RESULTS: After 12 generations, the 0.5 mg/L clarithromycin resistance strains remained resistant after the storage in -80℃ for 30 d. Clarithro-mycin-restant H pylori which had been inserted by transponson showed a band of 700 bp ......
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