肝硬化大鼠门静脉内毒素水平与Child-Pugh分级之间的关系
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殷云勤, 韩德五, 王新国
肠源性内毒素;Child-Pugh分级;肝硬化;四氯化碳,殷云勤,韩德五,王新国,殷云勤,讯作者,Associationbetweenp
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殷云勤, 韩德五, 王新国, 山西医科大学肝病研究所 山西省太原市 030001
殷云勤, 硕士, 山西医科大学肝病研究所博士生, 副主任医师.
通讯作者: 韩德五, 030001, 山西省太原市, 山西医科大学肝病研究所. smuhan@ty.sx.cn
电话: 0351-4135067
收稿日期: 2006-01-20 接受日期: 2006-02-21
Association between portal endotoxemia and Child-Pugh classification in complex pathogens-induced hepatic cirrhosis in rats
Yun-Qin Yin, De-Wu Han, Xin-Guo Wang
Yun-Qin Yin, De-Wu Han, Xin-Guo Wang, Institute of Hepatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Correspondence to: Dr. De-Wu Han, Institute of Hepatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. smuhan@ty.sx.cn
Received: 2006-01-20 Accepted: 2006-02-21
Abstract
AIM: To evaluate the association between the Child-Pugh classification and portal endotoxe-mia during the course of rat liver cirrhosis induced by carbon tetrachloride (CCl4) plus ethanol and cholesterol.
METHODS: Liver cirrhosis model was induced in 20 Wistar rats using CCl4 plus ethanol and cholesterol, while 6 rats were treated as controls. At 6 and 10 wk, serum samples were collected from portal vein for the detection of prothrombin time, albumin, bilirubin and endotoxin level, and the ascites and brain wave were also tested. The liver function was evaluated by Child-Pugh scoring system and the relationship between Child-Pugh classification and portal endotoxemia was assessed.
RESULTS: Spearman rank correlation analysis showed that Child-Pugh grading was correlated with albumin level and prothrombin time (r = -0.695, P < 0.05; r = 0.649, P < 0.05), but not with bilirubin level (P > 0.05). The level of endotoxin in portal vein was elevated with prolonging of cirrhosis time, and it was significantly higher at 6 or 10 wk than that in the controls (1983.7 ± 586.4, 2600.7 ± 343.8 mEU/L vs 925.1 ± 527.7 mEU/L, both P < 0.01). Endotoxin level was correlated with cirrhosis time (r = 0 ......
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