摘要：目的：观察无创正压机械通气对慢性阻塞性肺疾病(COPD)的临床治疗效果。方法：在80例COPD患者中随机选择了40例进行规律性无创双水平气道正压机械通气辅助治疗，每日上机两次，每次2h，2周为一疗程。比较上机前、上机2h、24h、1周、2周后动脉血气中pH值，PaO2值，PaCO2值及临床症状变化情况。结果：治疗组治疗2h、24h、1周、2周后动脉血气中pH值和PaO2值逐步上升，PaCO2值逐步下降，临床症状明显改善，有效率为87.5%(35/40)。对照组动脉血气中pH值，PaO2，PaCO2值及临床表现虽有不同程度的改善，但与治疗组同期比较，差异均有显著性(P<0.05)。结论：无创双水平气道正压机械通气辅助治疗COPD具有显著的临床治疗效果。

    关键词：肺疾病，阻塞性/治疗；呼吸；人工

    Clinical Study of the Noninvasive Mechanical Ventilation for Treatment of

    Chronic Obstructive Pulmonary Disease

    HUANG Xin-Su, ZHENG Zong-Mao, HAN Fei, et al

    (The Second Affiliated Hospital of Shantou Medical College,Guangdong Shantou 515041, China)

    Abstract: Objective: To evaluate the clinical efficacy of noninvasive mechanical ventilation for the treatment of patients with chronic obstructive pulmonary disease(COPD). Method: Eighty COPD patients were divided equally at random into two groups(1)mechanical ventilation and(2)no mechanical ventilation (as control). The first groups was treated with double channel noninvasive mechanical ventilator twice a day and 2 hours per time, each course lasted for 2 weeks. Arterial blood pH, PaO2 and PaCO2 were measured and changes of clinical symptoms were recorded in both groups before and 2 hours, 24 hours, 1 week and 2 weeks after treatment, respectively. Result: In first group, arterical Ph and PaO2 elevated gradually, accompany with gradual decline of PaCO2 and prominently clinical symptoms. Its effective rate of treatment was 87.5%(35/40). As for the control group, three parameters of arterial blood and clinical symptoms were also improved to a certain degree, but significant difference existed as compared with the first group(P<0.05).Conclusion: Noninvasive mechanical ventilation as an auxiliary treatment is definitely valuable for COPD patients. ......