胃肿瘤_____胃肿瘤；(期刊论文)

Ang2在胃癌组织中表达与胃癌新生血管形成的关系

http://www.100md.com 《咸宁学院学报(医学版)》 2005年第6期

胃肿瘤,,胃肿瘤；,促血管生成素2；新生血管形成；微血管密度,1资料与方法,2结果,参考文献：

     摘要：目的研究Ang2(angiopoietin2)在胃癌组织中的表达与胃癌新生血管形成的关系,并探讨其临床意义。方法用Western Blot法检测Ang2蛋白在10例胃癌组织及10例正常胃组织中的表达；用免疫组化法检测53例胃癌组织中Ang2蛋白的表达。结果 ①Ang2蛋白在正常胃组织中不表达,胃癌组织中呈阳性表达；②Ang2蛋白在胃癌的不同临床病理分期中表达强度不同，且随病程进展表达呈增强趋势，各组间差异有统计学意义；③胃癌组织中微血管密度(13±2/HP)和新生血管的数量(8±3/HP)明显高于正常胃组织(4±1/HP，阴性)。结论 Ang2参与了胃癌组织新生血管的形成及维持，该蛋白可以作为监测胃癌进展及评价预后的指标之一。

    关键词：胃肿瘤；促血管生成素2；新生血管形成；微血管密度

    The Expression of Angiopoietin2 in Gastric Carcinoma and Its Relation with Tumor Angiogenesis

    ZHU Peng,ZHENG Chaoxin,CHEN Daoda, et al

    (Department of Surgery,the First Affilated Hospital of Xianning College,Xianning Hubei 437100,China)

    ABSTRACT: Objective To study the expression of angiopoietin2 in gastric carcinoma tissue and its relationship with tumor angiogenesis,and to explore its clinical significance. Methods Immunohistochemical method was used to detect the expression of Ang2 protein in 53 samples of gastric cancer tissue, and western blot technique was used to detect the expression of Ang2 protein in 10 samples of gastric carcinoma tissues and 10 normal gastric tissues. Results Ang2 was expressed in tumor tissue, while normal tissue was unexpressed. The expression intensity of Ang2 was strongly associated with stages of tumor.The microvessel density(MVD,13±2/HP) and the average number of informed vessels (IMV,8±3/HP) of gastric carcinoma tissues were obviously higher than those of normal tissues(4±1/HP, negative) Conclusion Ang2 plays an important role in the progress of angiogenesis and tumor growth, it can be used to evaluate the growth of gastric carcinoma and predict prognosis in gastric cancer. ......

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