复方血竭胶囊对大鼠局灶性脑缺血再灌注损伤的拮抗作用
复方血竭胶囊,,复方血竭胶囊；脑缺血再灌注,1材料与方法,2结果,3讨论,参考文献：
摘要：目的 探讨复方血竭胶囊(CXJC)对局灶性脑缺血再灌注损伤大鼠的作用。方法 雄性SD大鼠40只，随机分为假手术组、缺血再灌注对照组、CXJC低剂量组(0.14 g·kg-1)、中剂量组(0.56 g·kg-1)和高剂量组(1.12 g·kg-1)，每组8只。采用大鼠大脑中动脉栓塞法制备大鼠脑缺血再灌注模型。缺血2 h再灌注24 h后，采用5级评分法判定大鼠神经功能缺损，按干湿重法计算脑组织含水量，TTC染色观察梗死灶体积。结果 低、中、高剂量CXJC均能降低缺血2 h再灌注3 h时的神经症状评分，其评分与模型对照组相比有显著性差异(P<0.01)，其中中剂量组于缺血2 h再灌6 h及24 h评分仍低于模型组，其差异有显著性(P<0.05)。低、中、高剂量CXJC组均能降低脑水肿和脑梗死体积，与模型对照组比较有显著性差异 (P<0.01或P<0.05)。结论 CXJC对脑缺血再灌注损伤具有保护作用。关键词：复方血竭胶囊；脑缺血再灌注
Protective Effects of Compound Xuejie Capsule on Focal Cerebral IschemiaReperfusion Injury in Rats
YU Donghui,WANG Hui,WU Jiliang,et al
(Department of Pharmacology, Medical College of Wuhan University, Wuhan Hubei 430071,China)
ABSTRACT:Objective To explore the effects of Compound Xuejie Capsule (CXJC) on focal cerebral ischemiareperfusion injury in rats. Methods 40 male SpragueDawley rats were randomly divided into five groups: sham group, ischemiareperfusion group, CXJC groups of low dose (0.14 g·kg-1), middle dose (0.56 g·kg-1) and high dose (1.12 g·kg-1). There were 8 animals in each group. The models of middle cerebral artery occlusion (MCAO) were established in rats. At 24h after MCAO, the extent of neurological deficit by scores grading on a scale of 0～4, cerebral edema with wet/dry weighing recorded and the size of cerebral infarction by TTC staining technique were determined. Results CXJC 0.14, 0.56 and 1.12 g·kg-1 were found decreasing neurological deficit scores at 3h after ischemiareperfusion (P<0.01), the scores at 6h and 24h in CXJC 0.56 g·kg-1 group was still lower than that of the ischemiareperfusion group (P<0.05). CXJC of three doses also decreased both infarction volumes and cerebral water contents (P<0.01 or P<0.05). Conclusion CXJC has protective effects on cerebral ischemicreperfusion injury in rats. ......
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