【摘要】 目的 研究肝抑素(HC)对大鼠实验性肝癌的治疗作用和作用环节。方法 采用二乙基亚硝胺(DEN)诱导法建立大鼠肝癌模型。观察大鼠肝脏的病理改变、肝表面癌结节数、肝重/体重。以甲胎蛋白(AFP)、γ-谷氨酰转肽酶(γ-GT)和碱性磷酸酶(ALP)作为观察指标。采用流式细胞仪检测肿瘤细胞的动力学变化。结果 大剂量HC的疗效优于阿霉素(ADM)，其作用环节是阻滞了G0～G1期细胞的增殖；中等剂量HC的疗效与ADM相似，但其作用环节则是阻滞了G2～M期细胞的增殖。结论 本研究证实了HC在体内应用能抑制肝癌细胞的增殖，延缓肝癌的发生发展。

    【关键词】 肝抑素； 大鼠； 肝肿瘤； 二乙基亚硝胺

    【Abstract】 Objective To study the therapeutic effect and protective effect of experimental hepatocellular carcinoma in rats with rabbit hepatic chalone(HC).Methods Hepatoma rats were induced by diethylnitrosamine(DEN).The changes of hepatoma nodules and ratio of liver/body weight were recorded and the alpha fetoprotein(AFP),γ-glutamyl transferase(γ-GT) and alkaline phosphatase(ALP) and the pathological changes of livers were observed.The cellular dynamic parameters were studied by flow cytometry.Results HC of high dose group was better than adriamycin(ADM) group,the protective effect might be to postpone advancement of G0-G1 phase cells.HC of appropriate dose group was the same as ADM group,and the protective effect might be to postpone advancement of G2-M phase cells.Conclusion The HC in this study could inhibit the prolifiration of hepatoma cells and delay the forming of hepatoma. ......