PHARMACYFeb.2005DPC4/SMAD4在子宫内膜癌中的表达及意义
子宫内膜癌,,Smad4蛋白；子宫内膜癌；免疫组织化学,1材料与方法,2结果,3讨论,参考文献
摘 要 目的 探讨Smad4蛋白在子宫内膜癌中的表达情况及其意义。 方法 应用免疫组织化学SP方法检测56例子宫内膜癌Smad4的表达情况，并与30例正常子宫内膜和42例各型增生性子宫内膜对比。结果 Smad4在子宫内膜癌中的表达明显低于正常子宫内膜和单纯性增生性子宫内膜(P<0.01，P<0.05)，且与组织学分级及临床分期明显相关(P<0.01，P<0.05)，而与肌层浸润深度无关。 结论 Smad4蛋白的表达可能在子宫内膜癌的发生发展及判断预后方面具有重要作用，可作为重要的生物学标记物。关键词 Smad4蛋白；子宫内膜癌；免疫组织化学
Expression of Smad4 protein in endometrial carcinoma and its significance
GE Xiujun，LIU Zhihui, LI Yingyong
(1. Department of obstetrics and gynecology, Guangdong College of Pharmacy，Guangzhou 510240,China; 2. Department of clinical laboratory, Affiliated Hospital of Traditional Medical University of Guangzhou, Guangzhou 510405,China; 3. Department of obstetrics and gynecology, Affiliated Hospital of Guangdong Medical College，Guangdong 524023,China)
Abstract Objective To investigate the expression of in endometrial carcinoma and its clinical significance. Methods Smad4 protein was detected in 56 endometrial carcinoma samples and 72 normal or/and benign hypertrophic endometrium samples by immunohistochemical SP method. Results Compared with normal controls and single hyperplasia, Smad4 protein was decreased in endometrial carcinoma tissue (P<0.01, P<0.05). The expression of Smad4 was correlated with histological grade and clinical stage (P<0.01, P<0.05) ......
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