糖尿病肾病__(期刊论文)

纤溶酶原激活物抑制物1与糖尿病肾病关系的研究

http://www.100md.com 《广东药学院学报》 2006年第1期

糖尿病肾病,,纤溶酶；原激活物抑制剂1；2型糖尿病；糖尿病肾病,1材料与方法,2结果,3讨论,参考文献:

     摘要:目的探讨2型糖尿病患者血浆中的纤溶酶原激活物抑制物1(PAI1)活性水平与2型糖尿病肾病(DN)的关系。方法选取2型糖尿病患者94例,按24 h尿白蛋白排泄率(UAER)分为无DN组(UAER<20 μg/min)、DN微量蛋白尿组(20 μg/min 200 μg/min)，选正常对照组26例。分别测定PAI1活性、血糖、血脂、胰岛素水平。结果 ①2型糖尿病患者血浆PAI1的活性显著高于正常对照组。②血浆PAI1活性在DN患者中升高，且随着DN的加重而呈递增趋势。③DN患者血浆PAI1活性与UAER、胰岛素抵抗指数(HOMEIRI)、空腹胰岛素(FI)、三酰甘油(TG)、体质量指数(BMI)正相关。结论 PAI1升高是DN的危险因素之一。胰岛素抵抗、高三酰甘油血症、肥胖可能是影响PAI1活性的重要因素。

    关键词:纤溶酶；原激活物抑制剂1；2型糖尿病；糖尿病肾病

    The relationship between plasminogen activator inhibitor1 and diabetic nephropathy

    WANG Shaobo，SHI Bingyin，WANG Yangwei，ZHANG Xinli

    (1.Department of Endocrine,The Peoples Hospital of Shaanxi Province,Xi an 710068,China;2. Department of Endocrine,the First Affiliated Hospital of Xian Jiaotong University,Xi an 710061,China)

    Abstract: Objective To investigate the relationship between plasminogen activator inhibitor1 and diabetic nephropathy. Methods 94 type 2 diabetic patients was divided into diabetes without nephropathy(the urine albumin excretion rate (UAER)<20 μg/min),diabetes with microalbuminural (20 μg/min 200 μg/min). The levels of PAI1,serum glucose,serum fasting insulin level and triglyceride were examined in all the diabetic patients and 26 healthy volunteers.Results ①The level of PAI1 activity increased in type 2 diabetes mellitus compared with controls. ②The level of PAI1 activity significantly increased in the group with diabetic nephropathy,and closely correlated with UAER. ③The level of PAI1 activity was correlated with UAER,homeostasis model assessmentinsulin resistance index (HOMEIRI),serum fasting insulin level (FI),triglyceride (TG) and body weight index (BMI). Conclusion High level of PAI1 activity was a risk of diabetic nephropathy,the insulin resistance,hypertriglyceridemia and obesity were important factors influencing PAI1. ......

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