脂质体凝胶_____补骨脂；脂质体凝胶；体外释药动力学

补骨脂素脂质体凝胶体外释药模式的考察

http://www.100md.com 《广东药学院学报》 2005年第1期

脂质体凝胶,,补骨脂；脂质体凝胶；体外释药动力学,1仪器与药品,2方法与结果,3讨论,参考文献

     摘要目的制备治疗白癜风的补骨脂素脂质体凝胶，对其体外释药模式进行定量考察。方法以同浓度的补骨脂素凝胶为对照，用透析法检测补骨脂素脂质体凝胶的体外释药模式，并对其在4 ℃下贮存3周的释药稳定性进行研究。结果与补骨脂素凝胶比较，补骨脂素脂质体凝胶具有明显的缓释及长效作用，且前3 h释药符合Higuchi扩散模式(k=4.67%h-1/2)，3 h后遵循零级释药模式(k=0.74%h-1)。而补骨脂素凝胶在实验的24 h内释药均符合Higuchi扩散模式(k=7.18%h-1/2)。在贮存期内，补骨脂素脂质体凝胶的释药模式及包封率均维持稳定。结论补骨脂素脂质体凝胶体外释药具有明显的缓释特征，稳定性理想，值得进一步研发。

    关键词补骨脂；脂质体凝胶；体外释药动力学

    Release profile of psoralen from liposomal gel formulation in vitro

    LUO Yun， He Wen，Li Rongling

    (Department of Pharmacy，Peoples Hospital of Wuhan University， Wuhan 430060，China)

    Abstract Objective To prepare the liposomeencapsulated psoralen and evaluate its drug release properties in vitro. Methods The drug release profiles of liposomeencapsulated psoralen were evaluated by dialyzation using psoralen gel as the control. Changes of liposomeencapsulated psoralen and release rate were detected during a 3week storage at 4 ℃ for evaluating the stability of the liposomal formulation. Results Compared with psoralen gel ......

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