头孢曲松__(期刊论文)

HPLC法测定胆道感染患者胆汁中头孢曲松浓度

http://www.100md.com 《广东药学院学报》 2003年第4期

头孢曲松,,头孢曲松；HPLC；胆道感染；个体化给药；,1仪器与试剂,2方法与结果,3讨论,参考文献

     摘要目的：建立胆汁中头孢曲松浓度的测定方法，用于临床个体化给药监测。方法：C18(200 mm×4.6 mm，5μm)色谱柱，流动相为ψ[甲醇∶水(0.015 mol/L溴化四丁基铵)]=40∶60，流速：1.0 mL/min，检测波长254 nm。结果：日内和日间RSD均小于5%。8名患者静脉滴注头孢曲松1 g，胆汁中药物峰浓度为14.37～2907μg/mL，8 h内胆汁排泄率0.28%～37.3%，个体差异较大。结论：方法简便、快速，可用于胆汁样品的CTRX浓度测定。胆汁中CTRX浓度取决于患者胆汁分泌情况，个体差异较大，应根据具体情况个体化给药。

    关键词头孢曲松；HPLC；胆道感染；个体化给药；

    Determination of the concentration of ceftriaxone in bile of biliary tract infection patients with HPLC

    HAN Liping,ZHANG Yanjun,LUO Ke

    (Department of Pharmacy,Guangzhou General Hospital of Guangzhou Military Command,Guangzhou,Guangdong 510010)

    Abstract Objective: To establish a method for the determination of ceftriaxone concentration in bile so as to monitor the clinical drug use. Methods: Spherisorb C18(4.6 mm×200 mm) column was used. Methanol∶water(0.015 mol/L Tetrabutyl Ammonium Bromide)(40∶60)was used as the mobile phase .The detection wavelength was 254 nm. Results: The level of RSD withinday and betweenday was ≤5%. 1.0 g ceftriaxone was given to each of 8 patients by intravenous drip and it reached Cmax= 19.05~2907μg/mL,bile excrete rate of CTRX was 0.28%～37.3% in 8 h. The individual diversity was prominent. Conclusion: The method is simple and convenient,and applicable to determine drug concentration in bile. ......

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