宫颈肿瘤_____](期刊论文)

Ⅰb-Ⅱa期巨块型宫颈癌术前介入化疗与放疗的近期疗效对比分析

http://www.100md.com 《实用医技杂志》 2006年第7期

宫颈肿瘤,,],宫颈肿瘤；介入性化疗；放射治疗；根治术；疗效,1材料和方法,2结果,3讨论,参考文献：

     [摘要] 目的：探讨术前介入化疗与放疗治疗Ⅰb-Ⅱa期巨块型宫颈癌的的近期疗效和价值。方法：对73例Ⅰb-Ⅱa期巨块型宫颈癌患者分组进行盆腔介入化疗与放疗，化疗组以卡铂300 mg/m2、平阳霉素50 mg/m2、长春新碱1 mg/m2进行介入治疗；放疗组采用腔内后装治疗，每周一次，每次A点剂量6 Gy~7 Gy，A点总剂量20 Gy~30 Gy。经治疗后3周进行宫颈癌根治术。结果:术前介入治疗组比放疗组肿瘤退缩明显，总有效率(CR+PR)%分别为89.5%和71.4%，差异有显著性(P<0.05)；介入化疗组与放疗组的淋巴结转移率分别为15.8%和17.1%，差异无显著性(P>0.05)。结论：Ⅰb-Ⅱa期巨块型宫颈癌患者术前行盆腔介入化疗近期疗效好于术前放疗者。

    [关键词] 宫颈肿瘤；介入性化疗；放射治疗；根治术；疗效

    Curative Effect of Intraarterial Neoadjucant Chemotherapy and Radiotherapy Before Radical Hysterectomy for 73 Cases with Massive Cervical Cancer in StageⅠb-Ⅱa

    XIAO Yong, HUANG Fengying， WANG Ge，et al

    (Huizhou Central People's Hospital, Huizhou, Guangdong 516001, China)

    Abstract：Objective: To study the curative effect of intraarterial chemotherapy and radiotherapy before radical excision for patients with massive cervical cancer in stage Ⅰb-Ⅱa. Methods 38 cases with massive cervical cancer in stageⅠb-Ⅱa were treated with a course of bilateral internal iliactery infusion of carboplatin 300mg/m2、doxorubicin 50 mg/m2 and vincristine 1 mg/m2 before radical hysterectomy.while the others were treated with middledoserate afterloading technigue in the radiatinon treatment(1times/week,6 Gy~7 Gy in A point/time,total dose was 20 Gy~30 Gy in A point.Results Patients treated with intraarterial chemotherapy achieved more significant effect than the others treated with radiotherapy (P<0.05). The rate of pelvic lymphnode metastasis between two groups has no significant effect.(P>0.05). Conclusion The patients treated with intra-arterial chemotherapy will get better curative effect than the others treated with radiotherapy. ......

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