儿童_____多态现象(遗传学)；儿童；智力；FRAXF

秦巴山区智力低下儿童FRAXF基因多态性研究

http://www.100md.com 《第四军医大学学报》 2006年第8期

儿童,,多态现象(遗传学)；儿童；智力；FRAXF,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Study on FRAXF gene polymorphism in children with mental retardation in Qinba mountain district

    ZHANG SuZhen, ZHANG FuChang, XIE XueJian, WEI YaNing, SHU Qing

    Department of Medical Genetics and Development Biology, School of Basic Medicine, 3Department of Cardiology, Fourth Military Medical University, Xian 710033, China, Institute of Population & Health, Northwest University, Xian 710069, China

    【Abstract】 AIM: To investigate the association between FRAXF gene polymorphism and the child intelligence in Qinba mountain district. METHODS: FRAXF genotype was detected in 84 mental retardation (MR) children and 74 normal controls by using PCR and polyacrylamide gel electrophoresis(PAGE) methods. The association of FRAXF gene polymorphism and the child intelligence was studied. RESULTS: Nineteen alleles had been checked out in MR group with the repeat frequency ranging 728. Twentyone alleles had been checked out in control group, the repeat frequency ranging 120. The distribution of FRAXF genotype was significantly different between MR and control groups(χ2=14.05, P<0.005). CONCLUSION: There was an association between FRAXF gene polymorphism and the child intelligence. FRAXF gene may be one of the candidate genes predisposing to MR. ......

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