奥美拉唑__(期刊论文)

2巯基5甲氧基1H苯并咪唑的合成

http://www.100md.com 《广东药学院学报》 2006年第1期

奥美拉唑,,2巯基5甲氧基1H苯并咪唑；奥美拉唑；中间体；合成,1实验部分,2讨论,参考文献:

     摘要:目的合成奥美拉唑中间体2巯基5甲氧基1H苯并咪唑。方法以4甲氧基2硝基苯胺为原料，经锌粉还原后，再与乙基黄原酸钾环缩合制得2巯基5甲氧基1H苯并咪唑。结果收率80%。结论该方法简单易行，适合工业化生产。

    关键词:2巯基5甲氧基1H苯并咪唑；奥美拉唑；中间体；合成

    Synthesis of 2mercapto5methoxybenzimidazole

    LIU YaRU， FENG Xuesong

    (School of Pharmacy，China Medical University,Shenyang 110001,China)

    Abstract: 2mercapto5methoxybenzimidazole,a key intermediate for the synthesis of omeperazole,was synthesized in 80% yield over two steps. Commercially available 2nitro4methoxyaniline was used as starting material and converted via reduction with zinc dust and cyclization with potassium ethyl xanthate into the title compound,suggesting that this procedure is suitable for industrial production.

    Key words:2mercapo5methoxybenzimidazole; omeperazole; intermediate; synthesis

    奥美拉唑(omeperazole)是由瑞典Astra公司开发研制的第一个质子泵(H+/K+ATP酶)抑制剂 ......

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