头孢克肟缓释片__(期刊论文)

头孢克肟缓释片体外释放度的研究

http://www.100md.com 《广东药学院学报》 2006年第1期

头孢克肟缓释片,,头孢克肟缓释片；释放度；紫外分光光度法,1仪器与试药,2方法与结果,4讨论,参考文献:

     摘要:目的建立头孢克肟缓释片释放度测定方法，评价其体外释药行为。方法用紫外分光光度法和释放度试验，考察头孢克肟缓释片在不同释放介质中不同释放时间的累积释放度。结果头孢克肟在288 nm处有最大吸收，在1.5～37.5 μg/mL范围内与吸收度呈良好的线性关系：A=0.0457ρ-0.0037,r=0.9999。头孢克肟缓释片在水、胃、肠液中1～16 h的体外释药行为理想，符合零级方程释药模型。结论本法简便、快速，适用于头孢克肟缓释片的质量控制。

    关键词:头孢克肟缓释片；释放度；紫外分光光度法

    In vitro release of cefixime sustainedrelease tablets

    GONG Wei,LI Yuanxin,ZHAO Leilei,ZHU Shengshan

    (Research and Development Institute of Chinese Materia Medica,Guangdong College of Pharmacy,Guangzhou 510240,China))

    Abstract: Objective To investigate in vivo drug release behaviors of cefixime sustainedrelease tablets. Methods Ultraviolet spectrophotometry and release test were applied to determine the release of cefixime in cefixime sustainedrelease tablets under different media and time points. Results Cefixime had the highest absorption peak at 288 nm and a good linearity within the range of 1.5～375 μg/ml (A＝0.0457C-0.0037,r＝0.9999). The release behavior of cefixime sustained-release tablets in water,artificial gastric juice and artificial intestinal juice could be best described by a zeroorder drug release pattern over 16 h in in vitro release studies. Conclusion This method is simple,quick and can be used for quality control of cefixime sustainedrelease tablets. ......

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