胆源性重症急性胰腺炎_____]_胆源性重症急性胰腺炎;

早期应用柴芩承气汤治疗胆源性重症急性胰腺炎的临床研究

http://www.100md.com 《中西医结合学报》 2005年第4期

胆源性重症急性胰腺炎,,],胆源性重症急性胰腺炎;,柴芩承气汤;,临床研究,1资料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的：探讨早期应用柴芩承气汤治疗胆源性重症急性胰腺炎(severe acute pancreatitis, SAP)的疗效。方法：90例符合病例选择标准并接受柴芩承气汤治疗的胆源性SAP住院患者，按院外病程长短分为早期组(3 d内入院接受治疗，54例)和晚期组(3～7 d内入院接受治疗，36例)，比较治疗过程中两组患者并发症的发生率、住院时间、手术中转率及病死率。结果：早期组胰性脑病、感染和消化道出血的发生率明显低于晚期组(P<0.05)。早期组和晚期组住院时间分别为(24.9±18.4)d和(51.6±45.9)d，早期组和晚期组病死率分别为7.4%(4/54例)和25.0%(9/36例)，早期组和晚期组中转手术率分别为11.1%(6/54例)和27.8%(10/36例)，两组比较差异均有统计学意义(P<0.05)。结论：早期应用柴芩承气汤治疗胆源性SAP，可减少并发症的发生、缩短住院时间、减少手术中转率及降低病死率。

    [关键词] 胆源性重症急性胰腺炎; 柴芩承气汤; 临床研究

    Clinical study of Chaiqin Chengqi Decoction in treating severe acute biliary pancreatitis

    XUE Ping, HUANG ZongWen, GUO Jia, ZHAO JianLei, LI YongHong, WANG ZhongChao

    (Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China)

    ABSTRACT Objective: To study the therapeutic effects of Chaiqin Chengqi Decoction (CQCQD) in treating severe acute biliary pancreatitis. Methods: Ninety patients with severe acute biliary pancreatitis were treated with CQCQD, and they were divided into two groups: earlytreated group (54 patients treated with CQCQD within 3 days after the onset of severe acute biliary pancreatitis) and latetreated group (36 patients treated with CQCQD between 3 and 7 days after the onset of severe acute biliary pancreatitis). The complication incidence rate, operation rate, mortality rate and hospitalization period were examined. Results: The incidence rates of encephalopathy, infection and gastrointestinal hemorrhage were lower in the earlytreated group than those in the latetreated group (P<0.05). The hospitalization periods of the early and latetreated groups were (24.9±18.4) days and (51.6±45.9) days respectively (P<0.05). The general mortality rate was 14.4%. The mortality rate of the earlytreated group (7.4%) was significantly lower as compared with that of the latetreated group (25.0%) (P<0.05). The operation rate of the earlytreated group (11.1%) was also significantly lower as compared with that of the latetreated group (27.8%) (P<0.05). Conclusion: Treating severe acute biliary pancreatitis with CQCQD in early stage may reduce the complication incidence rate, shorten the hospitalization period ......

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