小儿退热口服液__(期刊论文)

HPLC法测定小儿退热口服液中黄芩苷的含量

http://www.100md.com 《广东药学院学报》 2004年第3期

小儿退热口服液,,小儿退热口服液；高效液相色谱法；黄芩苷,1仪器与试药,2方法与结果,3讨论,参考文献

     摘要目的: 建立HPLC法测定小儿退热口服液中的有效成分黄芩苷含量的方法。方法: 采用色谱柱为C18柱，流动相为ψ甲醇∶水∶磷酸)=45∶55∶0.2，检测波长为315 nm。结果：黄芩苷在0.15~1.2 μg/mL范围内与峰面积呈线性关系，口服液中黄芩苷的平均回收率为98.07%，RSD=1.05%。结论：方法简便、稳定，能有效地控制该制剂的质量。

    关键词小儿退热口服液；高效液相色谱法；黄芩苷

    Determination on baicalin in Xiaoer Tuire oral liquid by HPLC

    ZHANG Xiaobing, WANG Xiaodong, WU Guoqiu, CHEN Yeqing

    (Guangzhou Huacheng Pharmaceutical Factory, Guangzhou，Guangdong 510555)

    Abstract Objective:to establish HPLC method for the determination of baicalin in the Xiaoer Tuire oral liquid. Method: the HPLC method was carried on C18 column using methodwatercodeine(45∶55∶0.2) as mobile phase. Detection wavelengthwas set at 315nm. Results: in the HPLC method the calibration curve for baicalin was linear over the range of 0.15～1.2μg/mL. The average recovery was 98.07% with RSD=1.05%. Conclusions: the method is simple, convenient and reliablefor quality control of the liquids.

    Key words Xiaoer Tuire oral liquids; HPLC; Baicalin

    小儿退热口服液系由大青叶、连翘、板蓝根、金银花、黄芩等十二味药材加工提取制得的口服液制剂 ......

百拇医药网 http://www.100md.com/html/DirDu/2006/05/31/98/12/36.htm

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