1_6二磷酸一镁__(期刊论文)

果糖1,6二磷酸一镁的稳定性研究

http://www.100md.com 《广东药学院学报》 2003年第3期

1,6二磷酸一镁,,果糖1，6二磷酸一镁；稳定性；有效期,1仪器与试药,2方法与结果,3讨论

     摘要目的：研究果糖1，6二磷酸一镁的稳定性，并确定产品有效期。方法：通过影响因素 (高温、高湿、强光照射)，加速试验，长期试验，采用高度专一性的酶法测定果糖1，6二磷酸一镁的含量变化,纸电泳法分析有关物质。结果：果糖1，6二磷酸一镁，在高温、高湿环境下不稳定，而对光较稳定。结论：果糖1，6二磷酸一镁，模拟上市包装，在温度(25±2) ℃，相对湿度(60±10)%的条件下保存24个月，仍符合质量标准。

    关键词果糖1，6二磷酸一镁；稳定性；有效期

    Studies on the stability of monomagnesium fructose1,6diphosphate

    WENG Wen,GAO Qin,ZHANG Peifen,Luo Huanmin

    (Drug Reserch Center,College of Pharmacy，JiNan University,Guangzhou,Guangdong 510632)

    Abstract Objective:To study the stability of monomagnesium fructose1,6diphosphate. Methods:An enzymatic method was used to determine the contents of monomagnesium fructose1,6diphosphate and a paper electrophoresis method was used to analyze the related substances under the conditions of severe test,accelerated test and longterm storage test. Results:monomagnesium fructose1,6diphosphate was unstable under heat and humidity. while it was stable under light. Conclusion:monomagnesium fructose 1,6diphosphate is in accordance with its quality standards afterpackaged and stored at 25 ℃±2 ℃,RH60%±10% for 24 months. ......

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