左金丸与反左金的方证对应实验研究
左金丸,,左金丸；反左金；方证对应,1材料,2方法,3结果,4讨论,参考文献
摘 要 目的 方证对应地比较研究左金丸与反左金的作用差异。方法 选用SD大鼠，以辣椒煎液和无水乙醇造成胃热证模型，以冰水和氢氧化钠造成胃寒证模型，比较左金丸和反左金对两个模型胃黏膜损伤的防治作用。结果 左金丸能明显防治胃热证模型大鼠的胃黏膜损伤(P<0.001)，对胃寒证模型则相对较差；与其相反，反左金对热模型无效，但能明显减轻胃寒证胃黏膜损伤(P<0.001)。结论 本研究验证了左金丸、反左金“寒能治热，热能治寒”的临床证治规律，为中医治疗的辨证施治宗旨提供了科学实验依据。关键词 左金丸；反左金；方证对应
Experiment of Zuojin Pills and Retro-ZuoJin by prescription corresponding to syndrome method
CHEN Yanfen，CHEN Weiwen, LI Ruliu
(1.Section of Chinese Materia Medica Pharmacology, Guangdong College of Pharmacy, Guangzhou, Guangdong 510240; 2.Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510405)
Abstract Objective To compare the different effects of Zuojin pills and RetroZuoJin by prescription corresponding to syndrome method. Methods the rats model of hotstomach syndrome was established by oral administration with anhydrous alcohol and pepper decoction; And the rats model of coldstomach syndrome was established by oral administration with ice water and sodium hydroxide. Based on these two models, the effects of Zuojin pills and RetroZuoJin were compared. Results Zuojin pills could distinctly prevent and cure hot gastric mucosa lesion (P<0.001), but acted relatively poor in coldstomach syndrome model. On the contrary, Retrozuojin seemed to have noeffect in hotstomach syndrome model, but it was suitable for cold gastric mucosa lesion (P<0.001). Conclusion this research verified the clinical regulation of Zuojin pills and RetroZuoJin and provided the experimental basis to the principle of treatment according to differentiation of symptoms and signs. ......
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