紫外分光光度法测定罗红霉素胶囊的含量
紫外分光光度法,,紫外分光光度法,；罗红霉素胶囊,；含量测定,1仪器与试药,2实验方法和结果,3讨论,参考文献
摘 要 目的 采用紫外分光光度法测定罗红霉素胶囊的含量。 方法 利用罗红霉素在482 nm波长处有最大吸收，而空白辅料在此处无吸收。 结果 罗红霉素在16.66~50.00 μg/mL浓度范围内，吸收度与浓度之间呈良好的线性关系(r=0.9999)；样品的平均回收率为100.2%，RSD=0.5%(n=9)。 结论 该方法操作简便，结果准确可靠，适用于该制剂的质量控制。关键词 紫外分光光度法 ；罗红霉素胶囊 ；含量测定
Determination of roxithromycin in roxithromycin capsules by UV spectrophotometry
HE Liming, ZHANG Huiwen , ZENG Xiaohui*
(Guangzhou Municipal Institute for Drug Control, Guangzhou, Guangdong 510160)
Abstract Objective To develop a UV method for the determination of roxithromycin. Methods roxithromycin was determined at 482 nm and blank control had little interference. Results The calibration curve was linear in the range of 16.66～50.00 μg/mL for roxithromycin and the correlation coefficient was 0.9999, The average recovery was 100.2%, with RSD of 0.5% (n=9). Conclusion The method is simple, accurate and was suitable for the determination of roxithromycin preparations.
Key words UV Spectrophotometry ; roxithromycin capsules; assaying
罗红霉素(Roxithromycin)系红霉素A的9位羰基以甲氧基乙氧基甲肟基取代的半合成红霉素 ......
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