盐酸二甲双胍__(期刊论文)

盐酸二甲双胍缓释片的相关物质研究

http://www.100md.com 《广东药学院学报》 2004年第3期

盐酸二甲双胍,,盐酸二甲双胍；缓释片；高效液相色谱法；相关物质,1试剂与仪器,2实验方法,3结果,3讨论,参考文献

     摘要目的：测定盐酸二甲双胍缓释片的相关物质。方法：采用HPLC法，色谱柱为SAULENTECHNIK Partisil-SCX(250 mm×4.6 mm,5μm)，流动相为1.7%磷酸二氢铵溶液，用磷酸调pH值至3.0，检测波长为289 nm，对盐酸二甲双胍缓释片的相关物质进行测定，并确定其限量。结果：本品的相关物质含量均小于0.1%。

    关键词盐酸二甲双胍；缓释片；高效液相色谱法；相关物质

    A study on the relative substances of metformin hydrochloride sustained-release tablets

    CHEN Yanzhong，LU Zhufen

    (Institute of Materia Medica, Guangdong College of Pharmacy, Guangzhou, Guangdong 510240)

    Abstract Objective: To assay the relative substances in metformin hydrochloride sustained-release tablets. Methods: Assay the relative substances in metformin hydrochloride sustained-release tablets with HPLC, with SAULENTECHNIK Partisil-SCX column (250 mm×4.6 mm, 5 μm), 1.7% ammonium dihydrogen phosphate as mobile phase, pH value was adjusted to 3.0 with phosphoric acid, and detection wavelength of 289 nm. The limits of the relative substances were determined. Results: The content of relative substances of metformin hydrochloride sustained-release tablets was less than 0.1%. ......

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