PolyoxWSR__(期刊论文)

盐酸地尔硫PolyoxWSR亲水凝胶骨架片的研究

http://www.100md.com 《广东药学院学报》 2004年第6期

PolyoxWSR,,PolyoxWSR；直接压片；亲水凝胶；骨架片,1材料和仪器,2实验方法及结果,3讨论,参考文献

     摘要目的研究亲水性树脂PolyoxWSR为凝胶缓释骨架的性能。方法以盐酸地尔硫为模型药物，采用粉末直接压片工艺制备亲水凝胶骨架片，考察影响骨架片释放度的因素和释药模型。结果 PolyoxWSR的黏度和用量、润滑剂的种类、压片粉末含水量对骨架片的释放度有影响；体外释放度显示骨架片的释放较接近零级方程和Higuchi方程。结论用PolyoxWSR作为亲水凝胶骨架片的基质能达到较好的缓释作用。

    关键词 PolyoxWSR；直接压片；亲水凝胶；骨架片

    Study on compressed hydrophilic matrices tablets of PolyoxWSR

    SONG Weifeng,LIN Huaqing,ZHENG Qiongliang,ZHUANG Hualing,LUO Shuai

    (1.The 3rd hospital of Zhongshan University, Guangdong, Guangzhou 510520,China; 2.Guangdong Collage of Pharmacy，Guangzhou 510240;3.Guangzhou Pharmaceutical Industial Institute，Guangzhou 510240,China)

    Abstract Objective To investigate the release performance of gel matrices sustained release tablets based on hydrophilic resin PolyoxWSR. Methods The hydrophilic gel matrices sustained release tablets containing diltiazem hydrochlride as a model drug were obtained by direct compression method. The effects of release and release model were observed. Results The content and the viscosity of PolyoxWSR, the kind of lubricants, and the moisture content of the direct compression powder can influence the release of diltiazem hydrochlride from matrix tablets.The drug release pattern from the matrix tablets was approach to Higuchi and zeroorder equation. Conclusion The PolyoxWSR can be used as a barrier to prepare a hydrophilic gel matrices sustained release tablets. ......

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