地西泮_____地西泮；咪哒唑仑；胃镜；镇静

胃镜中联合应用地西泮和咪哒唑仑的镇静效果和安全性观察

http://www.100md.com 《广东药学院学报》 2004年第2期

地西泮,,地西泮；咪哒唑仑；胃镜；镇静,1资料与方法,结果,3讨论

     摘要目的：探讨在胃镜检查(治疗)中联合应用地西泮和咪哒唑仑的镇静效果和安全性。方法：1 228例患者在胃镜检查(治疗)前依次静脉注射地西泮、咪哒唑仑，术中和术后严密观察患者的呼吸、脉搏、血压、血氧饱和度、镇静状态、遗忘程度及满意度。结果：1 226例顺利完成检查或治疗，2例终止；镇静程度2级1 014例(82.57%)；所有患者的呼吸、脉搏、血压未发现明显下降；22例血氧饱和度下降，最低为83%；术后1194例(97.23%)全遗忘，1226例(99.84%)表示满意。结论：适量联合应用地西泮和咪哒唑仑进行胃镜检查(治疗)是一种有效、安全的方法。

    关键词地西泮；咪哒唑仑；胃镜；镇静

    Study on the combined use of diazepam and midazolam during sedation gastroscopy

    YANG Qihong, SHU Jianchang, LIANG Shaojuan,LI Mingen,FENG Suling,YU Ruifang

    (Department of Gastroenterology, Guangzhou Red Cross Hospital, No. 4 Affiliated Hospital to the Medical College of Jinan University, Guangzhou,Guangdong 510220)

    Abstract Objective: To study the efficacy and safety of the combined use of diazepam and midazolam during sedation gastroscopy. Methods: 1 228 patients were given diazepam and midazolam intravenously just before gastroscopy. The pulse(P), respiration(R), blood pressure(BP), oxygen saturation (SaO2), sedative score, oblivion degree and satisfaction degree of all the patients were observed and recorded. Results: Gastroscopies were performed successfully in 1 226 patients, and failed in 2 patients. No abnormal P, R, BP changes of all the patients were found. Desaturation was found in 22 patients (minimum SaO2=83% ), and recovered soon after the procedure. 1 194 (97.23%) patients were compliant with the gastroscopy procedure completely. Satisfaction rate with the procedure was 99.84% (1 226/1 228). Conclusions: The combined use of diazepam and midazolam during sedation gastroscopy is effective and safe. ......

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