参麦活血饮_____](中国医学)

参麦活血饮对糖尿病大鼠早期周围神经病变的作用

http://www.100md.com 《中西医结合学报》 2005年第1期

参麦活血饮,,],参麦活血饮；糖尿病神经病变；动物，实验,1材料与方法,2结果,3讨论,[参考文献]

     [摘要] 目的：观察参麦活血饮对糖尿病大鼠感觉神经传导速度(sensory nerve conduction velocity，SNCV)及红细胞醛糖还原酶(aldose reductase，AR)活性和血浆内皮素(endothelin，ET)水平的影响，探讨其作用的可能机制。方法：采用链脲佐菌素(streptozotocin，STZ)诱发糖尿病大鼠模型，造模1周后用参麦活血饮治疗，用药4周后测定SNCV及红细胞AR活性和血浆ET水平。结果：糖尿病大鼠SNCV减慢，波幅减小，潜伏期延长，红细胞AR活性和血浆ET水平升高，与正常组相比差异显著(P<0.05)；参麦活血饮治疗组上述改变减轻,与糖尿病模型组相比差异显著(P<0.05)。结论：参麦活血饮有防治糖尿病大鼠早期周围神经病变的作用，其可能机制是阻断多元醇代谢通路及改善神经血供。

    [关键词] 参麦活血饮；糖尿病神经病变；动物，实验

    Effects of Shenmai Huoxue Decoction on early diabetic peripheral neuropathy in rats

    XUE HongLi, WANG WenJian, CHEN JianQiu

    (Institute of Chinese Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China)

    ABSTRACT Objective: To evaluate the effects of Shenmai Huoxue Decoction (SMHXD) on early diabetic peripheral neuropathy (DPN) in rats. Methods: The rats were randomly divided into 3 groups: normal group, diabetic model group and SMHXDtreated diabetic group. The diabetic rats were induced by streptozotocin (STZ) intraperitoneally. After the treatment, sensory nerve conduction velocity (SNCV) of caudal nerve was detected with evoked electromyography, and the activity of aldose reductase (AR) in erythrocytes and the concentration of endothelin (ET) in plasma were measured. Results: It was showed that the SNCV reduced significantly and the activity of AR in erythrocytes and the concentration of ET in plasma were increased significantly in diabetic group as compared with those in the normal group. The SNCV was increased, and the activity of AR in erythrocytes and the concentration of ET in plasma were improved significantly in SMHXDtreated diabetic group after the treatment. Conclusion: The results indicate that SMHXD can alleviate the lesion of DPN in the early stage of diabetic rats. ......

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