水杨酸软膏用乳化剂筛选研究
水杨酸,,水杨酸；软膏；乳化剂；稳定性,1实验,2结果与讨论,3结论,参考文献
摘 要 目的 为制备稳定的水包油型(O/W)水杨酸软膏，对乳化剂进行筛选。方法 用硬脂酸盐、十二烷基硫酸钠(K12)、烷基膦酸酯钾盐(MAP)、聚氧乙烯(2)硬脂醇醚 (Brij 72)、聚氧乙烯(21)硬脂醇醚(Brij 721)、单硬脂酸甘油酯和聚氧乙烯(100)硬脂酸酯混合乳化剂(Arlecal 165)等进行了水杨酸软膏配制试验。 结果 硬脂酸盐、MAP、Brij 72、Brij 721等乳化剂不适合用于水杨酸软膏的制备，K12及其与Arlecal 165的复配物作乳化剂则能制备稳定的水杨酸软膏。 结论 通过实验，选出了制备水杨酸软膏的最佳乳化剂，得到了水杨酸软膏的实用配方。关键词 水杨酸；软膏；乳化剂；稳定性
Formulation screening of emulsifier for salicylic acid ointment
GONG Shengzhao, WANG Zongrui
(1.Department of Chemical Engineering, Guangdong Industry Technical College, Guangzhou, Guangdong 510300； 2. Section of Pharmacology, Guangdong Medical College, Zhanjian,Guangdong 524003)
Abstract Objective Formulation screening of emulsifier for the preparation of oil in water(O/W) salicylic acid ointment. Methods The emulsifiers such as stearate, sodium dodecyl sulfate(K12), monolauryl phosphate(MAP), steareth2 (Brij 72), steareth21 (Brij 721), clyceryl stearate and PEG-10 stearate (Arlecal 165, Uniquema) were used in the formulation screening of emulsifier. Results The emulsifiers such as stearate, MAP, Brij 72, Brij 721 were not suitable for preparation of salicylic acid ointment. K12 and its mixture with Arlacel 165 can stabilize salicylic acid ointment. Conclusion The optimal and applicable formulation for emulsifier for the preparation of salicylic acid ointment was screened. ......
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