Establishment of rabbit VX2 renal carcinoma model and its manifestations in imaging examination

    SHE Junª²Jun, WANG Ziª²Ming, CHENG Wei, DAI Sheª²Jiao, BAI Zhiª²Lan, CHE Xiangª²Ming

    Department of Urology Surgery, Department of Radiology, Second Affiliated Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710004, China, Department of General Surgery, First Affiliated Hospital, Xi¬ðan Jiaotong University, Xi¬ðan 710061, China

    ¡¾Abstract¡¿ AIM: To establish rabbit VX2 renal carcinoma model and observe its manifestations in spiral CT, MRI and DSA. METHODS: VX2 renal carcinoma was induced in 20 New Zealand rabbits through VX2 carcinoma block transplantation, and then the carcinoma was examined through CT, MRI and angioª²graphy in different periods. RESULTS: Carcinoma formation rate was 100%. All the carcinomas were shown to be isointense or hypointense lesions through normal spiral CT. The carcinomas presented hypointense nodules and the enhanced edges through contrastª²enhanced spiral CT. The carcinomas presented comparatively uniform hypointense lesions in T1ª²WI MR images and hyperintense lesions in T2ª²WI MR images. Three weeks later, the carcinomas showed mixed nodules of hypointense and hyperintense because of liquefaction and necrosis. In renal artery angiography VX2 carcinoma showed hypervascular. CONCLUSION: The best stage for experimental researches of rabbit VX2 carcinoma model is 2-3 weeks after tumor transplantation. Spiral CT is suit to observe dynamicly and evaluate curative effect. The rabbit VX2 carcinoma model is fit for intervention research. ......