养肝利胆颗粒对小鼠四氯化碳肝损伤的保护作用
养肝利胆颗粒,,],养肝利胆颗粒;,四氯化碳;,超氧化物歧化酶;,丙二醛,1材料与方法,2结果,3讨论,[参考文献]
[摘要] 目的：观察养肝利胆颗粒对小鼠四氯化碳(carbon tetrachloride, CCl4)肝损伤的影响，并探讨其作用机制。方法：采用腹腔注射CCl4制作小鼠慢性肝损伤模型。造模3周后分别予以养肝利胆颗粒小、中、大剂量，胆宁片及联苯双酯治疗4周，检测各组血清丙氨酸氨基转移酶(alanine aminotransferase, ALT)，天门冬氨酸氨基转移酶(aspartate aminotransferase, AST)，肝组织超氧化物歧化酶(superoxide dismutase, SOD)活性和丙二醛(malondialdehyde, MDA)含量。结果：养肝利胆颗粒可显著降低小鼠CCl4肝损伤模型血清ALT、AST的水平和肝组织MDA的含量，明显升高肝组织SOD的水平。结论：养肝利胆颗粒对CCl4所致小鼠肝损伤有明显的改善作用，其作用机制可能与减轻肝内脂质过氧化反应有关。[关键词] 养肝利胆颗粒; 四氯化碳; 超氧化物歧化酶; 丙二醛
Protective effects of Yanggan Lidan Granules on carbon tetrachlorideinduced liver damage in mice
YOU ShengFu, ZHENG PeiYong, JI Guang, WEI HuaFeng, ZHAO Jie, ZHU PeiTing
(Center of Scientific Research, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Institute of Chinese Traditional Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China)
ABSTRACT Objective: To observe the protective effects of Yanggan Lidan Granules (YGLDG) on carbon tetrachloride (CCl4)induced liver damage in mice and to find out its mechanism. Methods: A model of chronic liver damage was established in mice by intraperitoneal injection of CCl4. After three weeks, those model mice were treated with low, medium, highdose YGLDG, Danning Tablets and bifendate respectively for four weeks. Then the levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in liver tissues were detected. Results: YGLDG could significantly reduce the levels of serum ALT and AST in model mice, and the content of MDA was obviously decreased while the content of SOD was increased in liver tissue. Conclusion: The therapeutic effect of YGLDG on mice with CCl4induced liver damage is to relieve the seriousness of liver damage, and its mechanism may relate to reducing peroxidation activity in liver tissue. ......
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