【摘要】 目的 探讨润肠丸延缓衰老的作用机制。方法 昆明种自然衰老小鼠45只随机分为老年空白对照组、老年阳性对照组、老年润肠丸组；昆明种青年小鼠30只随机分为青年空白对照组、青年润肠丸组各15只。均连续灌胃30日，检测各组小鼠的胸腺指数、脾脏指数、血清超氧化物歧化酶(SOD)活性(黄嘌呤氧化酶法)、丙二醛(MDA)(硫代巴比妥酸法)含量、乙酰胆碱酯酶(AchE)活力。结果 SOD、MDA、AchE及胸腺指数、脾脏指数，老年润肠丸组与老年空白对照组、老年阳性对照组比较均有显著性差异(P<0.05或P<0.01)；青年空白对照组与青年润肠丸组比较无显著性差异(P>0.05)。结论 润肠丸具有明显的延缓衰老作用，为“六腑以通为用”延缓衰老提供了科学依据。

    【关键词】 润肠丸；延缓衰老；实验研究

    Experimental research of Runchang pill on postpone senility

    LIN Haiyang, YU Jianing.

    Binzhou Medical College, Binzhou 256603

    【Abstract】 Objective To explore the postpone senility machenism of Runchang pill. Methods 45 senile mice were randomly divided into senile blank control group, senile positive control group and senile Runchang pill group. 30 juvenile mice were randomly divided into junile blank control group, juvenile Runchang pill group. Mice in the different groups were orally administraed different medicine for 30 days. Thymus index, spleen index, serum Superoxide dismutase (SOD) activity, MDA and AchE level were investigated. Results Runchang pill has obvious postpone senility function and provide scientific evidence for postpone senility. ......