冠心病痰瘀证与载脂蛋白E基因多态性关系的研究
冠心病,,],冠心病;,载脂蛋白E类;,基因多态性;,痰瘀证候,1资料与方法,2结果,3讨论,[参考文献]
[摘要] 目的:探讨冠心病(coronary heart disease, CHD)不同痰瘀证候与载脂蛋白E(apolipoprotein E, ApoE)基因第4外显子多态性的关系。方法:选择符合条件的CHD痰证、瘀证、痰瘀互阻证和非痰非瘀证(其他证型)患者200例,另选100名健康志愿者作为对照。常规检测所有样品的血脂水平。提取全血DNA,用聚合酶链反应限制性片段长度多态性(polymerase chain reactionrestriction fragment length polymorphism, PCRRFLP)技术检测ApoE基因型。采用SAS软件对基因多态性和痰瘀证候的辨证类型进行相关性分析。结果:(1)冠心病患者中ε4等位基因频率(19.5%)明显高于健康对照组(9.5%),具有统计学意义(P<0.05),其中尤以E 3/4基因型更为多见(P<0.01)。(2)携带ε4等位基因者的总胆固醇(total cholesterol, TC)、总甘油三酯(total triglycerides, TG)和低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol, LDLC)水平明显高于非携带者(P<0.01)。(3)痰证特别是E3/4基因型患者中E3/4型和ε4等位基因的频率明显高于血瘀证患者(P<0.05)。结论:ApoE ε4等位基因是冠心病的危险因素,携带此基因的患者与痰证关系较为密切,推测其可能是CHD痰证的主要易感基因之一。[关键词] 冠心病; 载脂蛋白E类; 基因多态性; 痰瘀证候
Study on relationship between polymorphism of apolipoprotein E gene and syndromes of phlegm and blood stasis in patients with coronary heart disease
OUYANG Tao, SONG JianNan, MIAO Yang, LIN Qian, NIU XiaoHong, JIN Hong, CHEN Bing
(Department of Biochemistry, Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing 100700, China; Department of Immunology, Beijing Institute of Geriatrics, Ministry of Public Health, Beijing 100730, China; Department of Cardiology, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China; Department of Cardiology, Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078, China) ......
您现在查看是摘要页,全文长 15014 字符。